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Showing posts with label beat depression. Show all posts
Showing posts with label beat depression. Show all posts

Thursday, 1 October 2015

Want to beat depression?

When I was in my early 20s, I suffered from suicidal despair. I cried for days, sobbed in the street, lost all my self-respect.
I won a prestigious scholarship to America to study ­literature for two years in ­Williamsburg, Virginia, and I became so ­desperately lonely that I took an overdose of sleeping pills. I was found outside my apartment by my flatmate and rushed to hospital, where they pumped out my stomach.
I’d always been a depressive, morbid ­character and suffered from panic attacks. I’d had a very difficult childhood, with a violent father who was addicted to powerful tranquillisers and attacked my mother and me.
Somewhere inside, I knew there was more to life than this. I tried softly-softly therapies such as psychiatry, ‘stress’ management and counselling. They promised to protect me from problems, but all they did was make me feel more helpless.
I could not bear to take antidepressants or tranquillisers because I had seen my father’s character changed by his addiction to them.
But I wasn’t getting better. During one panic attack, I ended up shutting myself in a phone box to ring for help, but I was shaking so badly I couldn’t dial the numbers.
For most of a decade I floundered, working through research, training and academic degrees in search of a magic mindset to make me happy and self-reliant. (I eventually ended up at the University of East Anglia as a research fellow investigating stress.)
Then I turned my research in a different direction, looking instead at what made ­people succeed in difficult or distressing ­circumstances. I studied sports psychology. I looked at the ancient character training used by the Roman army.
The secret, I learnt, was to develop resilience in the face of adversity; to face the problem and be deeply changed by that experience. I came to realise our modern approach to depression and despair often makes the problem worse.
We live in an unusually protective, safety-conscious society that thinks the way to help the weak and vulnerable is to nurse them like infants and prevent them from feeling bad. But look at the number of adults who are suffering from depression and anxiety today and ask yourself: softly-softly — is it helping or harming?
Today, one in three GP patient appointments involves a patient reporting depression. More than six million people in Britain regularly take antidepressants.
A study published just last week found two-thirds of women in England and Wales have suffered mental health problems such as ­anxiety and depression.
Depression is a pandemic, so it must have an underlying cause. I suggest it’s this: we have come to see negative emotions as an inconvenience or an illness. And our modern therapy culture is far too ready to give people labels for their distress — labels that make them feel mentally abnormal and unable to help themselves out of their troubles.
Many people believe they suffer from ‘depression’ or ‘clinical depression’ simply because they are grieving over one of life’s maulings, don’t know what to do to feel better and think it might help if they had a label for their bad feelings.
The label acts like a baby’s dummy or the security blanket of Charlie Brown’s best friend Linus in the Peanuts cartoon — he sucks his thumb and holds it to his ear in times of trouble, though it doesn’t actually serve any useful purpose.
This label is not a cure. It might actually demoralise you and prolong the whole bitter episode.
Once patients are officially labelled ‘depressed’, it tends to sap what little energy they have left to get off their bottoms and set about changing their outlook on life.
Poet John Keats described depression as the ‘drowsy numbness that pains the sense’. It is not only disastrous to life, but dangerous to health. It shouldn’t be mollified with tea and sympathy, but faced down and defeated.
Don't succumb: Your brain has untapped powers to help you (posed by model)
I had such an experience when I was young. I was starting out as a writer, living with my parents, and suffering from panic attacks that were becoming more and more distressing. My habit had been to try to escape the symptoms by surrounding myself with friends and keeping busy. But nights were terrifying spirals and I feared for my sanity.
One evening I decided I couldn’t outrun this any more: I was too exhausted. I’d turn and face the monster. So I went to my room, lay down, folded my arms and waited for the worst.
But suddenly, instead of terror, I felt absolute peace. I went downstairs and looked at my violent, drug-addicted father watching a film on television — On The Waterfront. I was overwhelmed with love and pity for my father, admiration for the film, gratitude for our tiny council house, the lamp on the television, the world I lived in. Everything suddenly made sense. I never suffered from panic attacks again.
Another term commonly applied to depressed people is that they are ‘traumatised’ by some terrible experience. We hear it all the time — schoolchildren have seen an accident in the playground and are therefore ‘traumatised’.
Viewers can apparently even be ‘traumatised’ by watching a particularly challenging episode of EastEnders. But well-conducted studies show that this label, too, can cause far more harm than good. For example, post-traumatic stress counselling can make people feel much worse after they have encountered something shocking.
It can convince them that their reactions are abnormal and a sign of mental illness, causing further anxiety, helplessness and disease.
In fact, negative emotions that go by the name of ‘stress’ can be ­bountifully positive.
A number of Nobel Prize-winning scientists have been studying what are technically known as ‘complex systems’. Examples of complex ­systems include piles of sand, pans of simmering water, the money ­markets and insect swarms.
At the highest point of tension and on the very edge of chaos, they ‘change gear’ and spontaneously produce order.
For example, when a pan of water is put on to boil, all the water molecules behave more and more randomly and ­chaotically until suddenly they all organise themselves into a hexagonal pattern of heat convection and then simmer. From the very edge of chaos emerges order.
‘Nothing to do with me,’ you might think. Except that one of the ­complex systems under study is the human brain, and whether it responds to tension in the same way. Undergoing tension and resolution might be crucial to its vital work.
The nervousness that our stress-managed age has come to fear and avoid might actually be part of a complex process designed to upgrade our abilities, and beat depression and despair.
When we face a threat or challenge, the body goes into the ­complex ‘fight-or-flight response’.
Stress management people are fond of telling us that this is a ‘very primitive’ threat mechanism — one that is suitable for fighting sabre-tooth tigers, but inappropriate for our modern lives.
The mechanism is, in fact, highly sophisticated. Scientists have revealed that it triggers a chain of hormonal and neurological ­reactions which mean that the brain, at the very height of a crisis that threatens to disintegrate us, can suddenly convulse its powers and produce a life-changing revelation.
This miraculous process, which in part is literally a carefully controlled ‘rush of blood’, is what rescued me when I was young and suffering from crippling anxiety.
The brain changes gear when we face threats and challenges. It has to. It is designed to help us survive and learn, to produce brilliant ideas when we’re in the middle of bad experiences. If we are numbed or coddled, we are denied these life-changing breakthroughs — the sudden moments of calm, clarity and visionary joy that occur at the very climax of a personal crisis.
So if you have been ‘diagnosed’, don’t just sit there and succumb. Your brain has untapped powers of recovery just lying there, waiting to help you survive and grow, waiting for you to say: ‘Blast all this. I’m going to get better.’
Source: http://www.dailymail.co.uk/health/article-1348114/Want-beat-depression-Do-I-did--just-grip.html


Thursday, 24 September 2015

What is depression?

There are times when we all feel sad, hopeless or fed up; it’s part of life. Depression is different. With depression these feelings don’t just go away. They can last for months, becoming so intense that carrying on with everyday life can become impossible.
Depression can be hard to spot. There are many different symptoms, some emotional and some physical. These are some of the most common, so if you've experienced four or more for most of the day, nearly every day for over two weeks, it might be time to talk to someone and visit your GP for help.

  • Tiredness and loss of energy
  • Persistent sadness
  • Loss of confidence and self-esteem
  • Difficulty concentrating and making decisions
  • Avoiding others and becoming isolated and lonely
  • Not being able to enjoy things that are usually pleasurable or interesting
  • Undue feelings of guilt or worthlessness
  • Feelings of helplessness and hopelessness
  • Sleeping problems - difficulties in getting off to sleep or waking much earlier than usual
  • Finding it hard to function at work/college/school
  • Change in appetite
  • Loss of sex drive and/ or sexual problems
  • Physical aches and pains
  • Thinking about suicide and death
  • Self-harm
It’s easy to blame ourselves, but depression can affect anyone. You might feel guilty or frustrated that you can’t find the motivation to keep up with things, and it can be especially hard to spot the symptoms if you’ve been feeling the same way for a long time. Many people find they also experience anxiety alongside their symptoms, so nausea, breathlessness and headaches are all signs that it might be time to get help.
Depression is common, and in its mildest form most people can lead a healthy and active life with the right treatment and support. On the more severe end, depression can be devastating and even life-threatening, so don’t go through it alone. Spotting the signs and getting help early can be vital, so talk to someone about it and visit your GP for help.
Source:  http://www.depressionalliance.org/information/what-depression

Sunday, 4 January 2015

Early exposure to antidepressants affects adult anxiety, serotonin transmission

About 15 percent of women in the United States suffer from anxiety disorders and depression during their pregnancies, and many are prescribed antidepressants. However little is known about how early exposure to these medications might affect their offspring as they mature into adults.
The answer to that question is vital, as 5 percent of all babies born in the U.S. -- more than 200,000 a year -- are exposed to antidepressants during gestation via transmission from their mothers.
Now, a UCLA team has studied early developmental exposure to two different antidepressants, Prozac and Lexapro, in a mouse model that mimics human third trimester medication exposure. They found that, although these serotonin-selective reuptake inhibiting antidepressants (SSRIs) were thought to work the same way, they did not produce the same long-term changes in anxiety behavior in the adult mice.
The mice exposed to Lexapro had permanent changes in serotonin neurotransmission and were less anxious as adults than the mice exposed to Prozac, said study senior author Anne M. Andrews, professor of psychiatry and chemistry and biochemistry and the Richard Metzner Endowed Chair in Clinical Neuropharmacology at the Semel Institute for Neuroscience & Human Behavior and California NanoSystems Institute.
"This was quite surprising, since these medications belong to the same drug class and are believed to work by the same mechanism. The implications of these findings are that with additional investigation, it may be possible to identify specific antidepressants that are safer for pregnant women," Andrews said. "It's important to recognize that major depressive disorders and anxiety disorders are serious medical conditions that often require therapeutic intervention. Prescribing the safest medication for mother and child is paramount."
The results of the six-year study appear early online Dec. 19, 2014 in the peer-reviewed journal Neuropsychopharmacology.
SSRIs like Prozac and Lexapro act by blocking the actions of a protein called the serotonin transporter, which removes the neurotransmitter serotonin from the signaling space between neurons. Andrews and her team also studied mice that had been genetically engineered to have a reduction or absence of serotonin transporters in the brain. They were able to compare early antidepressant exposure to permanent reductions in serotonin transporter function.
Genetic reductions in serotonin transporters are thought to be a risk factor, particularly when combined with stressful life experiences, for developing anxiety and mood disorders. And in fact, the genetically engineered mice Andrews studied showed more anxiety as adults.
"It might be possible that when mothers are treated for depression or anxiety during pregnancy that certain SSRIs may promote resilience to developing these disorders in children later in life," Andrews said. "However, it will take much more research for us to understand whether this is true and whether certain SSRIs may be better at promoting these effects."
Going forward, Andrews and her team plan to investigate the effects of early exposure to antidepressants on the architectures of serotonin neurons. Based on the current findings, they suspect that early exposure to Lexapro may alter the way serotonin neurons innervate brain regions involved in mood and anxiety behavior. They also plan to investigate other SSRIs such as Paxil and Zoloft.
"Current antidepressant therapies are ineffective in treating anxiety and depression in large numbers of patients, and advances in predicting individual responses are hindered by difficulties associated with characterizing complex influences of genetic and environmental factors on serotonergic transmission in humans," the study states. "Highly controlled animal models, such as those studied here, represent avenues by which to identify factors potentially influencing behavioral domains associated with emotion-related disorders."
Source: http://www.sciencedaily.com/releases/2014/12/141219160606.htm

Wednesday, 21 May 2014

How to beat depression – without drugs

Up to 20% of the UK population will suffer from depression – twice as many as 30 years ago, says Steve Ilardi. Photograph: Rob Lewine/Getty/Tetra
Dr Steve Ilardi is slim and enthusiastic, with intense eyes. The clinical psychologist is 4,400 miles away, in Kansas, and we are chatting about his new book via Skype, the online videophone service. "I've spent a lot of time pondering Skype," he says. "On the one hand it provides a degree of social connectedness. On the other, you're still essentially by yourself." But, he concludes, "a large part of the human cortex is devoted to the processing of visual information, so I guess Skype is less alienating than voice calls."
  1. The Depression Cure: The Six-Step Programme to Beat Depression Without Drugs
  2. by Steve Ilardi
Social connectedness is important to Ilardi. In The Depression Cure, he argues that the brain mistakenly interprets the pain of depression as an infection. Thinking that isolation is needed, it sends messages to the sufferer to "crawl into a hole and wait for it all to go away". This can be disastrous because what depressed people really need is the opposite: more human contact.
Which is why social connectedness forms one-sixth of his "lifestyle based" cure for depression. The other five elements are meaningful activity (to prevent "ruminating" on negative thoughts); regular exercise; a diet rich in omega-3 fatty acids; daily exposure to sunlight; and good quality, restorative sleep.
The programme has one glaring omission: anti-depressant medication. Because according to Ilardi, the drugs simply don't work. "Meds have only around a 50% success rate," he says. "Moreover, of the people who do improve, half experience a relapse. This lowers the recovery rate to only 25%. To make matters worse, the side effects often include emotional numbing, sexual dysfunction and weight gain."
As a respected clinical psychologist and university professor, Ilardi's views are hard to dismiss. A research team at his workplace, the University of Kansas, has been testing his system – known as TLC (Therapeutic Lifestyle Change) – in clinical trials. The preliminary results show, he says, that every patient who put the full programme into practice got better.
Ilardi is convinced that the medical profession's readiness to prescribe anti-depression medication is obscuring an important debate. Up to 20% of the UK population will have clinical depression at some point, he says – twice as many as 30 years ago. Where has this depression epidemic come from?
The answer, he suggests, lies in our lifestyle. "Our standard of living is better now than ever before, but technological progress comes with a dark underbelly. Human beings were not designed for this poorly nourished, sedentary, indoor, sleep-deprived, socially isolated, frenzied pace of life. So depression continues its relentless march."
Our environment may have evolved rapidly but our physical evolution hasn't kept up. "Our genome hasn't moved on since 12,000 years ago, when everyone on the planet were hunter- gatherers," he says. "Biologically, we still have Stone Age bodies. And when Stone Age body meets modern environment, the health consequences can be disastrous."
To counteract this Ilardi focuses on the aspects of a primitive lifestyle that militate against depression. "Hunter- gatherer tribes still exist today in some parts of the world," he says, "and their level of depression is almost zero. The reasons? They're too busy to sit around brooding. They get lots of physical activity and sunlight. Their diet is rich in omega-3, their level of social connection is extraordinary, and they regularly have as much as 10 hours of sleep." Ten hours? "We need eight. At the moment we average 6.7."
So we should all burn our possessions and head out into the forest? "Of course not," Iladi shudders. "That would be like a lifelong camping trip with 30 close relatives for company. Nobody would recommend that."
Instead we can adapt our modern lifestyle to match our genome by harnessing modern technology, such as fish oil supplements to increase our intake of omega-3. All well and good. But I can't escape the feeling that the six-step programme seems like common sense. Isn't it obvious that more sleep, exercise and social connectedness are good for you?
"The devil is in the detail," replies Ilardi. "People need to know how much sunlight is most effective, and at which time of day. And taking supplements, for example, is a complex business. You need anti-oxidants to ensure that the fish oil is effective, as well as a multivitamin. Without someone spelling it out, most people would never do it." Ilardi practises the programme himself. He's never been depressed, he tells me, but it increases his sense of wellbeing and reduces his absentmindedness (his college nickname was "Spaced").
It all makes sense, but will I try it myself? I don't suffer from depression, but wellbeing sounds nice. I'm not so sure about the fish oil, but I might just give it a go.

Enjoy the sunshine, get plenty of sleep – and be sociable

▶ Take 1,500mg of omega-3 daily (in the form of fish oil capsules), with a multivitamin and 500mg vitamin C.
▶ Don't dwell on negative thoughts – instead of ruminating start an activity; even conversation counts.
▶ Exercise for 90 minutes a week.
▶ Get 15-30 minutes of sunlight each morning in the summer. In the winter, consider using a lightbox.
▶ Be sociable.
▶ Get eight hours of sleep

Source: http://www.theguardian.com/lifeandstyle/2010/jul/19/beat-depression-without-drugs