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Showing posts with label fatigue. Show all posts
Showing posts with label fatigue. Show all posts

Thursday, 22 October 2015

How can you tell depression from simple sadness? If you're feeling down because of a specific event, such as losing a job or the breakup of a relationship, it could be normal and temporary sadness. If you feel sad, despairing, teary, or "empty" every day for more than two weeks and it's interfering with other aspects of your life, it may be clinical depression.

 Breaking Plans, Withdrawing Socially
Do you avoid leaving the house? Does making conversation feel like too much effort? Do you retreat to your bed when family members try to draw you out? Maintaining a strong social network is important. Losing pleasure in activities can indicate feelings of depression. It may help to join a support group of people who understand what you're going through.

 Sleeping Too Much or Too Little
A change in your sleeping habit such as insomnia -- trouble falling or staying asleep -- could be a sign of depression. It can cause or aggravate other symptoms that may also indicate depression, such as fatigue. If you regularly lie awake at night with your mind racing or sleep too much to avoid getting out of bed, speak to your doctor. If your sleep problems are a symptom of depression relapse, medication and talk therapy may help.

Irritability
Lately you've found it difficult to handle everyday stresses. Small things make you snap. You constantly bicker with friends and family. Where you used to be easygoing, you now have violent outbursts. Depression can show itself in irritability and anger. Men are more likely than women to behave recklessly and, sometimes, violently when they are depressed.

Loss of Interest in Sex and Other Pleasures
This is one of the most common signs of depression. Activities you used to enjoy may now feel like a burden. If you've had depression in the past and have lost feelings for your spouse or children, or lost interest in work, hobbies, or other favorite activities for more than two weeks, could you be relapsing? Ask your doctor for help. Symptoms recurring within a year put you at risk of a depression relapse.

Feeling Worthless

Tuesday, 16 June 2015

UC Irvine researcher finds biological link between chronic pain, mental illness

It’s understandable that people who are in constant physical pain would experience a high level of stress and fatigue.

But a recent study by researchers at UC Irvine and UCLA shows chronic pain sufferers also are more vulnerable to mental and emotional illnesses such as anxiety and depression and that there’s a biological link between the mental and physical pain.

Catherine Cahill, an associate professor of anesthesiology and perioperative care at UCI, has been working with colleagues at the UCLA Brain Research Institute to study the relationship between chronic pain and mood disorders.

The result? They found that chronic pain causes inflammation in regions of the brain that deal with reward and motivation, causing patients to be more susceptible to mood disorders.

Chronic pain is defined as pain lasting for an extended period, usually more than 12 weeks, according to the National Institutes of Health. More than 100 million Americans are affected by chronic pain, according to a recent report by the Institute of Medicine.

Cahill and the research team studied brain inflammation in rodents and its effect on the neural system. Their paper, published June 3 in The Journal of Neuroscience, shows a link between brain inflammation caused by chronic pain and mood disorders.

“Many studies in depression literature show that one of the causes for the development of mood disorders is a disruption in the dopamine circuitry,” Cahill said, referring to the brain chemical associated with happiness and pleasure. “My study was on the link between the very, very high (co-existence) of anxiety and depression in those patients with chronic pain. This was really never shown before.”

According to the study, the brain inflammation caused by pain triggers the activation of cells called microglia, which hinder the release of dopamine.

Cahill noted that the study has potentially significant implications on how doctors might treat future patients experiencing mood disorders alongside chronic pain. Her research, she added, also sheds light on addiction, an illness that’s affected by the reward and motivation system of the brain.

Cahill said she hopes her research can eventually have clinical impact. She is planning to test an existing drug compound that could restore the flow of dopamine.

“This is a new strategy to try to restore the reward circuitry that has both implications on addiction-like disorders and mood disorders,” she said..
Source:  http://www.ocregister.com/articles/-666693--.html